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Calc/stats help please
If anyone could explain how this is done step by step, it would be greatly appreciated.Genotypes AA, Aa, and aa occur with probabilities [θ2, 2θ(1-θ), (1-θ)2]. A multinomial sample of size n has frequencies (n1, n2, n3) of these three genotypes.
a) The likelihood of θ, L(θ), is θ2n1 + n2 • 2n2 • (1 - θ)n2 + 2n3.
Show that the negative of the second derivative of L(θ) with respect to θ2 (meaning [-∂2L(θ)] / ∂θ2] ) is equal to [(2n1 + n2)/θ2] + [(n2 + 2n3)/(1-θ)2] and that its expectation is 2n/[θ(1-θ)]. Use this to obtain an asymptotic standard error of θ.
b) Explain how to test whether the probabilities truly have this pattern.
2 comments
- By jaygat455 |
- Category: calculus |
- Grade level: college and above
- Feb/05/2010 |
- Answers to this question: 0
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